Oct 02 2008

The future of antidepressant pharmacotherapy

The future of antidepressant pharmacotherapy

Although there are many drugs and psychotherapies available for the treatment of depression, the overall care of depressed patients is usually far from optimal. This review examines how care might be improved in the future, by considering a number of alternative approaches: enhanced use of existing treatments, modifications to existing antidepressant drugs, new targets for antidepressant pharmacotherapy, and non-pharmacological physical treatments. It examines how advances in genetics and neuroscience may lead towards individualised drug treatment, but concludes cautiously, emphasising that theoretical treatment advances can only improve clinical outcomes if used rationally, in collaboration with the patient.

When considering the future of antidepressant treatment, the properties of the notional ‘ideal antidepressant’ need to be examined (Table 1). Clearly, no such drug exists at present. Furthermore, advances in neuroscience may lead to the development of more efficacious antidepressants, but if these are not readily acceptable to depressed patients the impact of new technologies is likely to be limited.

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Aug 21 2008

The Silent Treatment

Category: Laughter, Stress Managementifpa @ 11:52 pm

A man and his wife were having some problems at home and were giving each other the silent treatment. Suddenly, the man realized that the next day, he would need his wife to wake him at 5:00 AM for an early morning business flight.

Continue reading “The Silent Treatment”


Aug 21 2008

WHO DOES WHAT

Category: Laughter, Stress Managementadmin @ 11:39 pm

A man and his wife were having an argument about who should brew the coffee each morning.

The wife said, ‘You should do it, because you get up first, and then we don’t have to wait as long to get our coffee.’ The husband said, ‘ You are in charge of cooking around here and you should do it, because that is your job, and I can just wait for my coffee. ‘Wife replies, ‘No, you should do it, and besides, it is in the Bible that the man should do the coffee.’ Husband replies, ‘I can’t believe that, show me.’

So she fetched the Bible, and opened the New Testament and showed him at the top of several pages, that it indeed says……….’HEBREWS’

God may have created man before woman, but there is always a rough draft before the masterpiece.


Aug 21 2008

Mental Health Benefits of Laughter

Category: Anti-Aging Lifestyle!, Laughter, Stress Managementadmin @ 11:36 pm

Humor, Laughter and Health: Bringing more humor and laughter into our Lives

The sound of roaring laughter is far more contagious than any cough, sniffle, or sneeze. Humor and laughter can cause a domino effect of joy and amusement, as well as set off a number of positive physical effects. Humor and laughter strengthen our immune systems and help us recover from illness, as well as bring joy into our lives. The question is, how do we gain access to this priceless medicine?