Sep 28 2008
Ionic Currents as A New Potential Treatment for Adult Onset Diabetes and Prolonged Longevity
Author: Xanya Sofra-Weiss, Ph.D & Ali Mohamed, M.D.ABSTRACT
Individual phenotypic differences result in a variation of T4 to Free T3 conversion. Free T3 stimulates lipolysis. This leads to polymorphic and individualized lipid deposition patterns. Hyperthyroidism is associated with weight loss via an increase in metabolic rate and lipolysis. Hypothyroidism, on the other hand, is associated with weight gain via a decrease in metabolic rate.
A literature review by Guillermo et al (2003) has shown that the risk of thyroid dysfunction in Diabetic patients is two- to threefold higher than in the general population. A number of studies have shown that thyroid hormones represented by serum total T3 and T4 concentrations and serum Free T3 and T4 concentrations were significantly lower in obese non-insulin-dependent diabetics than control subjects. Low T3 is also a strong predictor of mortality in cardiac patients and may be directly implicated in the poor prognosis of cardiac patients.
The biological functions of GF (GH) are carried out by Insulin-like Growth Factor 1 (IGF-1). IGF-1 is the key determinant of somatic growth. It regulates puberty and gonadal function, and influences body composition as well as structural and functional maintenance of adult tissues. Loss of skeletal muscle mass, increased adiposity, and other unwelcome accompaniments of aging have been linked to age-related decline in pituitary GF secretion. On this basis, administration of GH is often advocated as an “anti-aging” therapy. However, administration of GF has a number of adverse side effects such as Diabetes, Carpal Tunnel Syndrome, joint and muscle pain, fluid retention, High Blood Pressure, etc. (Hintz, 2004). In addition, mutant GF deficient animals have demonstrated prolonged longevity (Corpas et al, 1993). Recent research in humans (Hoeijmakers et al, 2008) has shown that GF and IGF-1 may be associated with aging as a result of the system’s tendency to focus on growth, which diminishes its capacity to invest in maintenance and repair, i.e. “the survival response.” It would appear that when GH is given in the appropriate dosage to replace inadequate production, side effects are minimal or none. In contrast, when GH is administered to patients with adequate production, arthritis, due to joint overgrowth, entrapment of nerves, such as carpal tunnel syndrome, excessive sweating, Hyperglycemia or overt diabetes, and edema, may all occur.
Although the benefits of intensified insulin treatment in insulin-dependent Diabetes Mellitus are well recognized, a meta-analysis of 14 randomized controlled trials revealed the risk of severe Hypoglycemia, Ketoacidosis and mortality from acute metabolic causes with intensified insulin treatment. These 14 trails contributed 16 comparisons with 1028 patients allocated to intensified and 1039 allocated to conventional treatment. A total of 846 patients suffered at least one episode of severe hypoglycaemia, 175 patients experienced ketoacidosis and 26 patients died.
We are investigating an alternative treatment for Diabetes with no side effects. This involves the enhancement of endogenous production of Free T3 and IGF-1 via an electronically designed ionic signal. The mechanism of this therapeutic signal delivery was invented by Pollock, (1990-2008), in Innovations Science, a European Community-funded research center. Using the Pacemaker technology this ionic signal produces the physiological responses associated with strenuous exercise. Pollock’s ionic signal initially targets the motor neurons resulting in rhythmical muscle contractions equivalent to performing high resistance physical activity. Once the process is initiated by Pollock’s bio-identical electronic signal, the motor neurons signal the brain via the spinal cord. This is a physiologically reversed process, like traffic being driven the opposite way, where the strenuous exercise signal does not originate in the brain traveling down the spinal cord to the motor nerve. Instead, the process is initiated at the peripheral motor neuron, then the circuit is completed by outgoing CNS neuron emission. This CNS emission causes the ultimate production of Free T3 and GH/IGF-1, which in turn cause lipolysis and muscular hypertrophy. The enhanced production of Free T3 and GF/IGF-I will temporarily cause hyperglycemia. However, the hyperglycemia will resolve once the glucose has been utilized for metabolic purposes including increased cellular energy and muscular hypertrophy. The aim of this study is to test the hypothesis that the use of ionic currents may reduce or eliminate adult onset Diabetes.
To meet and share your view with the author, we invite you to attend “The
Prestigious 7th Asia Pacific Conference on Anti-Aging Medicine and
Regenerative Biotechnology, 10-12 October 2008 at Grand Hyatt, Bali –
Indonesia” Register NOW!
Prof. Michael Klentze, MD, PhD, ABAARM
