Anti-Aging Today!

ScienceDirect - Archives of Gerontology and Geriatrics : Is consensus in anti-aging medical intervention an elusive expectation or a realistic goal?

One of the biggest scandals of the recent history of medicine is the conflict of views between the gerontological establishment and the American Academy of Anti-Aging Medicine (A4M). The style used in that discussion was really rough and unusual. On the one hand, according to some representatives of the American Medical Associations (AMA), the use of human growth hormone (hGH) for anti-aging medical interventions is illegal, criminal, and requires persecution. On the other hand, A4M is of the opinion that all this is “…filled with incorrect, misplaced references and studies, and multiple basic scientific errors, in an apparent attempt to damage the anti-aging medical profession…”. It is evident that in the frame of a short article is impossible to treat all the relevant aspects of this complicated story. Nevertheless, this Editorial attempts to point out the main results obtained so far, together with the most important issues of theoretical feasibility of the hGH replacement therapy (hGHRT). The comprehensive explanation of the aging process called “membrane hypothesis of aging” (MHA) offers a solid basis for the interpretation of the observed beneficial effects of the hGH through its practically ubiquitous membrane receptors, and the species specificity of this peptide hormone. The specific activation of these receptors stimulates the membrane transport functions, rehydrates the intracellular colloids, allowing to speed up the protein synthesis and turnover, and activates a great number of cellular functions, all observed so far. The facts known about the adult growth hormone deficiency (AGHD) syndrome, and the beneficial effects of hGHRT in all aspects of this pathology suggest that aging may generally be considered as an AGHD syndrome. If this concept is accepted by most of the gerontologists, we can resolve practically all problems involved in the above outlined controversies. All this requires an independent, open-minded approach to the problem, and pushes us to a better understanding of the results of theoretical aging research. This approach may open a new, realistic way to the development of efficient anti-aging medical interventions.

Expose on Crimes Against Humanity as Perpetrated by the Gerontological Elite Asks Is Consensus in Anti-Aging Medical Intervention An Elusive Expectation or A Realistic Goal?

Expose on Crimes Against Humanity as Perpetrated by the Gerontological Elite Asks Is Consensus in Anti-Aging Medical Intervention An Elusive Expectation or A Realistic Goal?

In the May-June 2009 issue of the prestigious Archives of Gerontology and Geriatrics, an international journal integrating experimental, clinical, and social studies on aging published by Elsevier, founder and Editor-in-Chief Prof. Dr. Imre Zs.-Nagy delivers an intrepid Expose revealing a decade-long calculated campaign of deceit, fraud, and suppression by the gerontological elite, which has threatened physician licensures and liberties to treat and prescribe life-improving therapies, leading potentially to the direct compromise of patients’ health and longevity. This profile of the sharp and protracted conflict of views between the gerontological establishment and the American Academy of Anti-Aging Medicine (A4M) exposes, as Prof. Dr. Zs.-Nagy describes, a “disregard by certain individuals bearing some of the most prestigious affiliations in the gerontological establishment, for truth, academic integrity, and scientific professionalism.”

FactCheck.org: Obama’s Stem Cell Spinning

An Obama-Biden radio ad hammers McCain for being opposed to stem cell research. Not true. Meanwhile two spots from the McCain-Palin campaign, together with the Republican National Committee, describe McCain’s support for the research; they’re largely accurate.

By saying that “John McCain has stood in the way – he’s opposed stem cell research,” the Obama ad seriously misstates the view that McCain has held on this issue since 2001, when he began backing embryonic stem cell research, a position that was out of step with that of many of his fellow Republicans.

The McCain/RNC ads would probably lead listeners to believe that Palin shares McCain’s views on this topic. That’s not true. But we find that to be a minor flaw compared with the misrepresentation in Obama’s ad.

Vitamin C may blunt effect of chemotherapy: study - Yahoo! News

WASHINGTON (Reuters) - Vitamin C supplements may undercut the effectiveness of cancer drugs including Novartis’ Gleevec, a U.S. study published on Wednesday showed.
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When used on human cancer cells treated with a form of vitamin C in lab dishes, chemotherapy drugs killed 30 percent to 70 percent fewer tumor cells than usual, the scientists wrote in the journal Cancer Research.

Dr. Mark Heaney of Memorial Sloan-Kettering Cancer Center in New York and colleagues also implanted human cancer cells into mice, and found that when mice got vitamin C supplements two hours before chemotherapy, the tumors grew more quickly.

InteliHealth:

Most diseases are caused by the death of healthy cells in a particular organ. For example, diabetes is caused by the death of insulin-producing cells in the pancreas (an organ that lies beneath the stomach); Parkinson’s disease is caused by the death of brain cells that produce a chemical called dopamine; and heart attacks cause the death of heart muscle cells. Almost all the organs in our bodies cannot, on their own, replace the cells that die (the liver is an exception). Nor have we discovered medicines that prompt our bodies to replace dead cells.

Stem cells have the capability to replace cells that have died, in different organs. In mice, stem cells have in fact replaced dead cells, and cured the mice of particular diseases (including heart muscle damage). That is why there is such excitement about using stem cells for what is called “cell therapy.”

* The Basics of Stem Cells
* The Unique Capabilities of Stem Cells
* How Stem Cells Help Treat Human Diseases
* Making Embryonic Stem Cells
* The Ethical Debate Over Embryonic Stem Cells

Study: Postmenopausal hormones via gel, patch less risky for heart - USATODAY.com

A study of hormone use in nearly 700,000 Danish women over 50 suggests that when it comes to heart attack risk, patches or gels are safer than the combination pills most American women use.

The authors say this is the largest postmenopausal hormones study since the Women’s Health Initiative, which randomly assigned 27,000 U.S. women to estrogen or estrogen-plus-progestin pills or to a placebo.

Osteoarthritis solutions: Good news on bad knees - USATODAY.com

The recent news that a common knee surgery does nothing for osteoarthritis of the knee might have sounded like bad news to some patients: one less chance at relief from pain and stiffness.

But experts in arthritis care say the results give them a chance to talk about good news: There’s a lot you can do to prevent or treat this increasingly common problem.

“Most people accept osteoarthritis as a part of aging and have this misperception that there’s nothing you can do,” says Patience White, chief public health officer for the Arthritis Foundation and a rheumatologist in Washington, D.C. “There is no quick fix, but there are things you can do.”

The future of antidepressant pharmacotherapy

Although there are many drugs and psychotherapies available for the treatment of depression, the overall care of depressed patients is usually far from optimal. This review examines how care might be improved in the future, by considering a number of alternative approaches: enhanced use of existing treatments, modifications to existing antidepressant drugs, new targets for antidepressant pharmacotherapy, and non-pharmacological physical treatments. It examines how advances in genetics and neuroscience may lead towards individualised drug treatment, but concludes cautiously, emphasising that theoretical treatment advances can only improve clinical outcomes if used rationally, in collaboration with the patient.

When considering the future of antidepressant treatment, the properties of the notional ‘ideal antidepressant’ need to be examined (Table 1). Clearly, no such drug exists at present. Furthermore, advances in neuroscience may lead to the development of more efficacious antidepressants, but if these are not readily acceptable to depressed patients the impact of new technologies is likely to be limited.

To learn more about innovative therapies for wellness and healthy aging management, we invite you to attend “The Prestigious 7th Asia Pacific Conference on Anti-Aging Medicine and Regenerative Biotechnology, 10-12 October 2008 at Grand Hyatt, Bali – Indonesia”  Register NOW!

Ionic Currents as A New Potential Treatment for Adult Onset Diabetes and Prolonged Longevity - iContact Community

Author: Xanya Sofra-Weiss, Ph.D & Ali Mohamed, M.D.

ABSTRACT

Individual phenotypic differences result in a variation of T4 to Free T3 conversion. Free T3 stimulates lipolysis. This leads to polymorphic and individualized lipid deposition patterns. Hyperthyroidism is associated with weight loss via an increase in metabolic rate and lipolysis. Hypothyroidism, on the other hand, is associated with weight gain via a decrease in metabolic rate.

A literature review by Guillermo et al (2003) has shown that the risk of thyroid dysfunction in Diabetic patients is two- to threefold higher than in the general population. A number of studies have shown that thyroid hormones represented by serum total T3 and T4 concentrations and serum Free T3 and T4 concentrations were significantly lower in obese non-insulin-dependent diabetics than control subjects. Low T3 is also a strong predictor of mortality in cardiac patients and may be directly implicated in the poor prognosis of cardiac patients.

The biological functions of GF (GH) are carried out by Insulin-like Growth Factor 1 (IGF-1). IGF-1 is the key determinant of somatic growth. It regulates puberty and gonadal function, and influences body composition as well as structural and functional maintenance of adult tissues. Loss of skeletal muscle mass, increased adiposity, and other unwelcome accompaniments of aging have been linked to age-related decline in pituitary GF secretion. On this basis, administration of GH is often advocated as an “anti-aging” therapy. However, administration of GF has a number of adverse side effects such as Diabetes, Carpal Tunnel Syndrome, joint and muscle pain, fluid retention, High Blood Pressure, etc. (Hintz, 2004). In addition, mutant GF deficient animals have demonstrated prolonged longevity (Corpas et al, 1993). Recent research in humans (Hoeijmakers et al, 2008) has shown that GF and IGF-1 may be associated with aging as a result of the system’s tendency to focus on growth, which diminishes its capacity to invest in maintenance and repair, i.e. “the survival response.” It would appear that when GH is given in the appropriate dosage to replace inadequate production, side effects are minimal or none. In contrast, when GH is administered to patients with adequate production, arthritis, due to joint overgrowth, entrapment of nerves, such as carpal tunnel syndrome, excessive sweating, Hyperglycemia or overt diabetes, and edema, may all occur.

Although the benefits of intensified insulin treatment in insulin-dependent Diabetes Mellitus are well recognized, a meta-analysis of 14 randomized controlled trials revealed the risk of severe Hypoglycemia, Ketoacidosis and mortality from acute metabolic causes with intensified insulin treatment. These 14 trails contributed 16 comparisons with 1028 patients allocated to intensified and 1039 allocated to conventional treatment. A total of 846 patients suffered at least one episode of severe hypoglycaemia, 175 patients experienced ketoacidosis and 26 patients died.

We are investigating an alternative treatment for Diabetes with no side effects. This involves the enhancement of endogenous production of Free T3 and IGF-1 via an electronically designed ionic signal. The mechanism of this therapeutic signal delivery was invented by Pollock, (1990-2008), in Innovations Science, a European Community-funded research center. Using the Pacemaker technology this ionic signal produces the physiological responses associated with strenuous exercise. Pollock’s ionic signal initially targets the motor neurons resulting in rhythmical muscle contractions equivalent to performing high resistance physical activity. Once the process is initiated by Pollock’s bio-identical electronic signal, the motor neurons signal the brain via the spinal cord. This is a physiologically reversed process, like traffic being driven the opposite way, where the strenuous exercise signal does not originate in the brain traveling down the spinal cord to the motor nerve. Instead, the process is initiated at the peripheral motor neuron, then the circuit is completed by outgoing CNS neuron emission. This CNS emission causes the ultimate production of Free T3 and GH/IGF-1, which in turn cause lipolysis and muscular hypertrophy. The enhanced production of Free T3 and GF/IGF-I will temporarily cause hyperglycemia. However, the hyperglycemia will resolve once the glucose has been utilized for metabolic purposes including increased cellular energy and muscular hypertrophy. The aim of this study is to test the hypothesis that the use of ionic currents may reduce or eliminate adult onset Diabetes.

To meet and share your view with the author, we invite you to attend “The
Prestigious 7th Asia Pacific Conference on Anti-Aging Medicine and
Regenerative Biotechnology, 10-12 October 2008 at Grand Hyatt, Bali –
Indonesia”  Register NOW!

Are the free radical and neuro-endocrine theories of aging now defunct in 2008? What determines aging and how can we prevent it? - iContact Community

To meet and share your view with the author, we invite you to attend “The Prestigious 7th Asia Pacific Conference on Anti-Aging Medicine and Regenerative Biotechnology, 10-12 October 2008 at Grand Hyatt, Bali – Indonesia”

Register NOW!

ABSTRACT
Are the free radical and neuro-endocrine theories of aging now defunct in 2008? What determines aging and how can we prevent it?
Author: Dr Michael Elstein, MD, ABAARM, FACNEM, FAAM

In 2008 the free radical and neuro-endocrine theory of aging is undergoing a major revamp. While the notion that free radical stress compromises mitochondrial function leading to degeneration and apoptosis as well as irrevocable nuclear DNA damage and destruction alternative evidence posits the view that the superoxide anion and peroxynitrite constitute regulated second messengers which are essential for normal cellular physiological function. (1) This might explain the findings of the recent review presented in JAMA 2007, which demonstrates that treatment with beta-carotene, vitamin A and vitamin E may increase mortality. (2) It might further be the basis for the discussion which shows that vitamin E might actually interfere with the oxidation of omega-3 fatty acids which in turn stimulates the formation of post-endoplasmic reticulum pre-secretory proteolysis to limit apolipoprotein-B. (3) Thus vitamin E actually interferes with an atherogenic inhibiting process which might go some way to explaining the increased mortality and morbidity in the trials that used vitamin E.

Tags: Anti-Aging & Regenerative Medicine